5QCC
Crystal structure of human Cathepsin-S with bound ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cathepsin S | polymer | 223 | 24516.5 | 2 | UniProt (P25774) Pfam (PF00112) In PDB | Homo sapiens (Human) | |
2 | A, B | tert-butyl 4-(2-{3-(4-chloro-3-iodophenyl)-1-[3-(morpholin-4-yl)propyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}-2-oxoethyl)piperidine-1-carboxylate | non-polymer | 712.1 | 2 | Chemie (BGY) | |||
3 | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 217 (UniProt: P25774)
PDB | External Database | Details |
---|---|---|
Ser 25 | Cys 139 | engineered mutation |
Leu 218 | - | expression tag |
Gln 219 | - | expression tag |
Gly 220 | - | expression tag |
Gly 221 | - | expression tag |
Gly 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49032.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1424.1 | |
All* | Total formula weight | 50457.1 |