5QBW
Crystal structure of human Cathepsin-S with bound ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cathepsin S | polymer | 223 | 24516.5 | 1 | UniProt (P25774) Pfam (PF00112) In PDB | Homo sapiens (Human) | |
| 2 | A | N-{[2-chloro-5-(2-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-3-oxo-2,3-dihydropyridazin-4-yl)phenyl]methyl}-4-fluorobenzamide | non-polymer | 663.6 | 1 | Chemie (B8S) | |||
| 3 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A: 0 - 217 (UniProt: P25774)
| PDB | External Database | Details |
|---|---|---|
| Ser 25 | Cys 139 | engineered mutation |
| Leu 218 | - | expression tag |
| Gln 219 | - | expression tag |
| Gly 220 | - | expression tag |
| Gly 221 | - | expression tag |
| Gly 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24516.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 25180.0 |
