5Q19
Ligand binding to FARNESOID-X-RECEPTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Bile acid receptor | polymer | 233 | 27100.2 | 2 | UniProt (Q96RI1) Pfam (PF00104) | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | B, D (B, D) | COACTIVATOR PEPTIDE SRC-1 HD3 | polymer | 14 | 1790.0 | 2 | UniProt (A8K1V4) UniProt (by SIFTS) (Q15788) | Homo sapiens | |
| 3 | E, F (A, C) | (2S)-N,2-dicyclohexyl-2-[2-(2,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]acetamide | non-polymer | 475.6 | 2 | Chemie (9N1) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, C: 248 - 476 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | expression tag |
| Ser 245 | - | expression tag |
| His 246 | - | expression tag |
| Met 247 | - | expression tag |
| Ala 281 | Glu 291 | conflict |
| Ala 354 | Glu 364 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57780.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 951.2 | |
| All* | Total formula weight | 58731.7 |
