5Q17
Ligand binding to FARNESOID-X-RECEPTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bile acid receptor | polymer | 233 | 27100.2 | 1 | UniProt (Q96RI1) Pfam (PF00104) In PDB | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | B | Nuclear receptor coactivator peptide SRC2 | polymer | 12 | 1464.7 | 1 | UniProt (A0A0B6XJZ8) UniProt (by SIFTS) (Q15596) In PDB | Homo sapiens | SRC2, STEROID RECEPTOR COACTIVATOR-2, NCOA-2 |
| 3 | A | 4-({5-bromo-2-oxo-1'-[(thiophen-2-yl)sulfonyl]spiro[indole-3,4'-piperidin]-1(2H)-yl}methyl)benzoic acid | non-polymer | 561.5 | 1 | Chemie (9MV) | |||
| 4 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A: 248 - 476 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | expression tag |
| Ser 245 | - | expression tag |
| His 246 | - | expression tag |
| Met 247 | - | expression tag |
| Ala 281 | Glu 291 | conflict |
| Ala 354 | Glu 364 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28564.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 561.5 | |
| All* | Total formula weight | 29126.3 |
