5PZP
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 4-FLUORO-2-(4-FLUOROPHENYL)-N-METHYL-5-(2-METHYL-5-{[1-(PYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}PHENYL)-1-BENZOFURAN-3-CARBOXAMIDE (BMS-929075)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-directed RNA polymerase | polymer | 574 | 63961.5 | 2 | UniProt (Q9WMX2) Pfam (PF00998) | Hepatitis C virus genotype 1b (isolate Con1) (HCV) | |
| 2 | C, L (A, B) | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid | non-polymer | 630.7 | 2 | Chemie (23E) | |||
| 3 | D, M (A, B) | 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide | non-polymer | 538.5 | 2 | Chemie (8XJ) | |||
| 4 | E, F, G, H, N... (A, B) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | I, J, K, R (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | S, T (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 573 (UniProt: Q9WMX2)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127923.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3475.4 | |
| All* | Total formula weight | 131398.5 |
