5PZL
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-({3-[1-(2-CYCLOPROPYLETHYL)-6-FLUORO-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL]-1,1-DIOXO-1,4-DIHYDRO-1LAMBDA~6~,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-directed RNA polymerase | polymer | 574 | 63961.5 | 2 | UniProt (Q9WMX2) | Hepatitis C virus genotype 1b (isolate Con1) (HCV) | |
| 2 | C, H (A, B) | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid | non-polymer | 630.7 | 2 | Chemie (23E) | |||
| 3 | D, I (A, B) | 2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda~6~,2,4-benzothiadiazin-7-yl}oxy)acetamide | non-polymer | 500.5 | 2 | Chemie (8XV) | |||
| 4 | E, F, G, J, K... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | N, O (A, B) | water | water | 18.0 | 753 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 573 (UniProt: Q9WMX2)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127923.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2934.9 | |
| All* | Total formula weight | 130857.9 |
