5P9J
BTK1 COCRYSTALLIZED WITH IBRUTINIB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase BTK | polymer | 279 | 32326.1 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A | 1-[(3~{R})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | non-polymer | 442.5 | 1 | Chemie (8E8) | |||
| 3 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32326.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 442.5 | |
| All* | Total formula weight | 32768.6 |
