5P9F
BTK IN COMPLEX WITH GDC-0834
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 279 | 32326.1 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B (A) | N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl }-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | non-polymer | 596.7 | 1 | Chemie (2VL) | |||
| 3 | C, D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H (A) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32326.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 937.1 | |
| All* | Total formula weight | 33263.2 |
