5OXG
Crystal structure of the ACVR1 (ALK2) kinase in complex with LDN-212854
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Activin receptor type-1 | polymer | 301 | 34537.6 | 4 | UniProt (Q04771) Pfam (PF00069) In PDB | Homo sapiens (Human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | A, B, C, D | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | non-polymer | 406.5 | 4 | Chemie (B4B) | |||
| 3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138150.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1928.5 | |
| All* | Total formula weight | 140079.0 |
