5ORS
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 265 | 30798.2 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | cyclobutyl-[4-(2-methoxyphenyl)piperidin-1-yl]methanone | non-polymer | 273.4 | 1 | Chemie (A5W) | |||
| 5 | F (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 127 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 290 | Cys 290 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30798.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 749.2 | |
| All* | Total formula weight | 31547.4 |
