5OOI

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Casein kinase II subunit alpha'	polymer	364	42879.9	2	UniProt (P19784) Pfam (PF00069)	Homo sapiens (Human)	CK II alpha'
2	C, J (A, B)	4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione	non-polymer		363.4	2	Chemie (9YE)
3	D, E, F (A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	G (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	H, I, K, L (A, B)	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
6	M, N (A, B)	water	water		18.0	443	Chemie (HOH)

Sequence modifications

A, B: 1 - 350 (UniProt: P19784)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Ser 336	Cys 336	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85759.7
Non-Polymers*	Number of molecules	10
	Total formula weight	1172.3
All*	Total formula weight	86932.0

*Water molecules are not included.