5OKO
Crystal structure of human SHIP2 Phosphatase-C2 double mutant F593D/L597D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | polymer | 461 | 52720.3 | 2 | UniProt (O15357) | Homo sapiens (Human) | Inositol polyphosphate phosphatase-like protein 1,INPPL-1,Protein 51C,SH2 domain-containing inositol 5'-phosphatase 2,SHIP-2 |
| 2 | C, D, E, F, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | H (B) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 288 | Chemie (HOH) |
Sequence modifications
A, B: 420 - 878 (UniProt: O15357)
| PDB | External Database | Details |
|---|---|---|
| Gly 418 | - | expression tag |
| Pro 419 | - | expression tag |
| Asp 593 | Phe 593 | engineered mutation |
| Asp 597 | Leu 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 105440.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 592.7 | |
| All* | Total formula weight | 106033.4 |
