5OGP
Metalacarborane inhibitors of Carbonic Anhydrase IX
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 259 | 29053.8 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | cobaltcarborane | non-polymer | 410.7 | 1 | Chemie (9UK) | |||
4 | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
A: 2 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | conflict |
Gln 67 | Asn 67 | conflict |
Val 69 | Glu 69 | conflict |
Leu 91 | Ile 91 | conflict |
Val 130 | Phe 130 | conflict |
Ala 203 | Leu 203 | conflict |
Val 223 | Leu 223 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29053.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 476.1 | |
All* | Total formula weight | 29529.9 |