5OGN
Metalacarborane inhibitors of Carbonic Anhydrase IX
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Carbonic anhydrase 2 | polymer | 259 | 29120.8 | 2 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A, B | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
3 | A, B | cobaltcarborane | non-polymer | 424.7 | 2 | Chemie (B8B) | |||
4 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
His 2 | - | expression tag |
Ser 65 | Ala 65 | conflict |
Gln 67 | Asn 67 | conflict |
Thr 69 | Glu 69 | conflict |
Leu 91 | Ile 91 | conflict |
Val 130 | Phe 130 | conflict |
Glu 169 | Lys 169 | conflict |
Ala 203 | Leu 203 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58241.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1045.7 | |
All* | Total formula weight | 59287.2 |