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5OEH

Molecular tweezers modulate 14-3-3 protein-protein interactions.

Replaces:  4HQW
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
14-3-3 protein sigmapolymer23626542.91UniProt (P31947)
Pfam (PF00244)
Homo sapiens (Human)Epithelial cell marker protein 1,Stratifin
2B
(A)
(1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaenenon-polymer726.61Chemie (9SZ)
PubChem (176626571)
PubChem (46908663)
PubChem (25023394)
PubChem (87765573)
PubChem (101513638)
PubChem (156621421)
PubChem (160952952)
PubChem (162773289)
PubChem (163760097)
PubChem (156621419)
PubChem (157798222)
PubChem (162773292)
PubChem (163474370)
3C
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
PubChem (312)
4D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
PubChem (753)
5E
(A)
waterwater18.093Chemie (HOH)
Sequence modifications
A: 1 - 231 (UniProt: P31947)
PDBExternal DatabaseDetails
Gly -4-expression tag
Ala -3-expression tag
Met -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight26542.9
Non-Polymers*Number of molecules3
Total formula weight854.2
All*Total formula weight27397.1
*Water molecules are not included.

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PDB entries from 2026-05-06

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