5OCH

The crystal structure of human ABCB8 in an outward-facing state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D (A, C, D)	ATP-binding cassette sub-family B member 8, mitochondrial	polymer	612	66540.8	3	UniProt (Q9NUT2) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (Human)	Mitochondrial ATP-binding cassette 1,M-ABC1
2	B (B)	ATP-binding cassette sub-family B member 8, mitochondrial	polymer	612	66597.9	1	UniProt (Q9NUT2) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (Human)	Mitochondrial ATP-binding cassette 1,M-ABC1
3	E (E)	ATP-binding cassette sub-family B member 8, mitochondrial	polymer	612	66597.9	1	UniProt (Q9NUT2) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (Human)	Mitochondrial ATP-binding cassette 1,M-ABC1
4	F, G (F, G)	ATP-binding cassette sub-family B member 8, mitochondrial	polymer	612	66597.9	2	UniProt (Q9NUT2) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (Human)	Mitochondrial ATP-binding cassette 1,M-ABC1
5	H (H)	ATP-binding cassette sub-family B member 8, mitochondrial	polymer	612	66483.8	1	UniProt (Q9NUT2) Pfam (PF00005) Pfam (PF00664)	Homo sapiens (Human)	Mitochondrial ATP-binding cassette 1,M-ABC1
6	CA, I, L, O, Q... (H, A, B, C, D...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	8	Chemie (ADP)
7	AA, DA, J, M, P... (G, H, A, B, C...)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG) PubChem (888)
8	BA, EA, K, N, S... (G, H, A, B, D...)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	7	Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028)

Sequence modifications

A, C, D: 111 - 714 (UniProt: Q9NUT2)

PDB	External Database	Details
Met 110	-	initiating methionine
Ala 715	-	expression tag
Glu 716	-	expression tag
Asn 717	-	expression tag
Leu 718	-	expression tag
Tyr 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag

B: 111 - 714 (UniProt: Q9NUT2)

PDB	External Database	Details
Met 110	-	initiating methionine
Ala 715	-	expression tag
Glu 716	-	expression tag
Asn 717	-	expression tag
Leu 718	-	expression tag
Tyr 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag

E: 111 - 714 (UniProt: Q9NUT2)

PDB	External Database	Details
Met 110	-	initiating methionine
Ala 715	-	expression tag
Glu 716	-	expression tag
Asn 717	-	expression tag
Leu 718	-	expression tag
Tyr 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag

F, G: 111 - 714 (UniProt: Q9NUT2)

PDB	External Database	Details
Met 110	-	initiating methionine
Ala 715	-	expression tag
Glu 716	-	expression tag
Asn 717	-	expression tag
Leu 718	-	expression tag
Tyr 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag

H: 111 - 714 (UniProt: Q9NUT2)

PDB	External Database	Details
Met 110	-	initiating methionine
Ala 715	-	expression tag
Glu 716	-	expression tag
Asn 717	-	expression tag
Leu 718	-	expression tag
Tyr 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	532497.6
Non-Polymers*	Number of molecules	23
	Total formula weight	7019.1
All*	Total formula weight	539516.7

*Water molecules are not included.