5OCA

PCSK9:Fab Complex with Dextran Sulfate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proprotein convertase subtilisin/kexin type 9	polymer	126	14107.8	1	UniProt (Q8NBP7) Pfam (PF05922) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	B	Proprotein convertase subtilisin/kexin type 9	polymer	540	57328.6	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
3	H	Fab from LDLR competitive antibody: Heavy chain	polymer	238	25489.3	1		Homo sapiens (Human)
4	L	Fab from LDLR competitive antibody: Light chain	polymer	217	22626.9	1		Homo sapiens (Human)
5	C	2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose	branched		742.6	1	In PDB BIRD (PRD_900071) GlyTouCan (G96300CN)		Heparan sulfate disaccharide
6	B	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7		water	water		18.0	788	Chemie (HOH)

Sequence modifications

A: 31 - 152 (UniProt: Q8NBP7)

PDB	External Database	Details
Gly 27	-	expression tag
Ala 28	-	expression tag
Met 29	-	expression tag
Gly 30	-	expression tag

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ile 474	Val 474	conflict
Ala 533	Asn 533	conflict
Gly 620	Glu 620	conflict
Glu 670	Gly 670	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	119552.6
Branched	Number of molecules	1
	Total formula weight	742.6
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	120341.2

*Water molecules are not included.