5O8V
Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 360 | 41359.3 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (Human) | MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
| 2 | B (A) | ~{N}-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]propanamide | non-polymer | 411.5 | 1 | Chemie (9O2) | |||
| 3 | C (A) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Cys 251 | Ser 251 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41359.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 411.5 | |
| All* | Total formula weight | 41770.8 |
