5O8U
Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 360 | 41359.3 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
2 | A | 4-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]butan-2-one | non-polymer | 410.5 | 1 | Chemie (9O5) | |||
3 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Cys 252 | Ser 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41359.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 410.5 | |
All* | Total formula weight | 41769.8 |