5O83
Discovery of CDZ173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 941 | 107951.8 | 1 | UniProt (O35904) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Mus musculus (Mouse) | PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta |
| 2 | B (A) | Leniolisib | non-polymer | 450.5 | 1 | Chemie (9NQ) | |||
| 3 | C (A) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 106 - 1044 (UniProt: O35904)
| PDB | External Database | Details |
|---|---|---|
| Gln 104 | - | expression tag |
| Gly 105 | - | expression tag |
| Gln 508 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 107951.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 450.5 | |
| All* | Total formula weight | 108402.2 |
