5O3B

Human Brd2(BD2) mutant in complex with AL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Bromodomain-containing protein 2	polymer	114	13361.4	4	UniProt (P25440) Pfam (PF00439)	Homo sapiens (Human)	O27.1.1,Really interesting new gene 3 protein
2	E, F, G, H (A, B, C, D)	methyl (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]pent-4-enoate	non-polymer		450.9	4	Chemie (9HZ)
3	I, J, K, L (A, B, C, D)	water	water		18.0	559	Chemie (HOH)

Sequence modifications

A, B, C, D: 344 - 455 (UniProt: P25440)

PDB	External Database	Details
Ser 342	-	expression tag
Met 343	-	expression tag
Val 383	Leu 383	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	53445.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1803.7
All*	Total formula weight	55249.2

*Water molecules are not included.