5O31
Mitochondrial complex I in the deactive state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13058.5 | 1 | UniProt (P03898) Pfam (PF00507) | Bos taurus (Bovine) | NADH dehydrogenase subunit 3 |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 179 | 20104.5 | 1 | UniProt (P42026) Pfam (PF01058) | Bos taurus (Bovine) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 228 | 26464.8 | 1 | UniProt (P23709) Pfam (PF00329) | Bos taurus (Bovine) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 430 | 49236.4 | 1 | UniProt (P17694) Pfam (PF00346) | Bos taurus (Bovine) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 217 | 23840.4 | 1 | UniProt (P04394) Pfam (PF01257) | Bos taurus (Bovine) | NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50718.8 | 1 | UniProt (P25708) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Bos taurus (Bovine) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35688.8 | 1 | UniProt (P03887) Pfam (PF00146) | Bos taurus (Bovine) | NADH dehydrogenase subunit 1 |
| 8 | H (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20219.9 | 1 | UniProt (P42028) Pfam (PF12838) | Bos taurus (Bovine) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 9 | I (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19082.5 | 1 | UniProt (P03924) Pfam (PF00499) | Bos taurus (Bovine) | NADH dehydrogenase subunit 6 |
| 10 | J (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10800.2 | 1 | UniProt (P03902) Pfam (PF00420) | Bos taurus (Bovine) | NADH dehydrogenase subunit 4L |
| 11 | K (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68327.9 | 1 | UniProt (P03920) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Bos taurus (Bovine) | NADH dehydrogenase subunit 5 |
| 12 | L (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52130.8 | 1 | UniProt (P03910) Pfam (PF01059) Pfam (PF00361) | Bos taurus (Bovine) | NADH dehydrogenase subunit 4 |
| 13 | M (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39274.9 | 1 | UniProt (P03892) Pfam (PF00361) Pfam (PF06444) | Bos taurus (Bovine) | NADH dehydrogenase subunit 2 |
| 14 | N (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 36739.7 | 1 | UniProt (P34942) Pfam (PF01712) | Bos taurus (Bovine) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 15 | O (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | polymer | 297 | 25294.0 | 1 | Bos taurus | ||
| 16 | P (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 98 | 10966.6 | 1 | UniProt (Q02370) Pfam (PF05047) | Bos taurus (Bovine) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 17 | Q, R (T, U) | Acyl carrier protein, mitochondrial | polymer | 88 | 10119.5 | 2 | UniProt (P52505) Pfam (PF00550) | Bos taurus (Bovine) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 18 | S (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 115 | 13203.4 | 1 | UniProt (P23935) Pfam (PF04716) | Bos taurus (Bovine) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 19 | T (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 15083.5 | 1 | UniProt (Q02366) Pfam (PF13233) | Bos taurus (Bovine) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 20 | U (Y) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14772.0 | 1 | UniProt (Q8HXG6) Pfam (PF02466) | Bos taurus (Bovine) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 21 | V (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8117.4 | 1 | UniProt (Q02377) Pfam (PF15879) | Bos taurus (Bovine) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 22 | W (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 80 | 7860.5 | 1 | UniProt (Q02371) Pfam (PF14987) | Bos taurus (Bovine) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit,Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 23 | X (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 49 | 5836.7 | 1 | UniProt (Q02376) Pfam (PF15088) | Bos taurus (Bovine) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 24 | Y (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12491.3 | 1 | UniProt (Q02379) Pfam (PF10200) | Bos taurus (Bovine) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 25 | Z (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6978.1 | 1 | UniProt (Q02378) Pfam (PF08040) | Bos taurus (Bovine) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 26 | AA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 125 | 14469.1 | 1 | UniProt (Q8HXG5) Pfam (PF10183) | Bos taurus (Bovine) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 27 | BA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 111 | 10739.9 | 1 | UniProt (Q02367) | Bos taurus (Bovine) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit,Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 28 | CA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2 | polymer | 52 | 4443.5 | 1 | Bos taurus | ||
| 29 | DA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 74 | 6315.8 | 1 | Bos taurus | ||
| 30 | EA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 | polymer | 120 | 10230.6 | 1 | Bos taurus | ||
| 31 | FA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 136 | 16297.6 | 1 | UniProt (Q02368) Pfam (PF05676) | Bos taurus (Bovine) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 32 | GA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 169 | 16906.9 | 1 | UniProt (Q02373) Pfam (PF10249) | Bos taurus (Bovine) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 33 | HA (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17115.5 | 1 | UniProt (O97725) Pfam (PF05071) | Bos taurus (Bovine) | Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 34 | IA (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 704 | 77044.1 | 1 | UniProt (P15690) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF00111) | Bos taurus (Bovine) | Complex I-75kD,CI-75kD |
| 35 | JA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 75 | 8451.4 | 1 | UniProt (P25712) Pfam (PF15880) | Bos taurus (Bovine) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 36 | KA (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 133 | 15361.3 | 1 | UniProt (Q02375) Pfam (PF04800) | Bos taurus (Bovine) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 37 | LA (R) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 96 | 10551.7 | 1 | UniProt (P23934) Pfam (PF10276) | Bos taurus (Bovine) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 38 | MA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 112 | 12564.4 | 1 | UniProt (Q05752) Pfam (PF07347) | Bos taurus (Bovine) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 39 | NA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 143 | 16752.4 | 1 | UniProt (Q02380) Pfam (PF09781) | Bos taurus (Bovine) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 40 | OA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 116 | 12923.2 | 1 | UniProt (Q02827) Pfam (PF06374) | Bos taurus (Bovine) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 41 | PA (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 19992.9 | 1 | UniProt (P42029) Pfam (PF06747) | Bos taurus (Bovine) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 42 | QA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 15075.1 | 1 | UniProt (P48305) Pfam (PF07225) | Bos taurus (Bovine) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 43 | RA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 178 | 21696.7 | 1 | UniProt (Q02369) Pfam (PF05347) | Bos taurus (Bovine) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 44 | SA (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 15369.3 | 1 | UniProt (Q95KV7) Pfam (PF06212) | Bos taurus (Bovine) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 45 | AB, BB, TA, WA, XA... (G, B, F, I) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 46 | CB, UA (G, E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 47 | VA (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 48 | ZA (P) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 49 | DB (R) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
D: 1 - 430 (UniProt: P17694)
b: 1 - 45 (UniProt: Q02371)
b: 46 - 80 (PDB: 5O31)
e: 1 - 105 (UniProt: Q02379)
i: 1 - 32 (UniProt: Q02367)
i: 40 - 118 (PDB: 5O31)
p: 4 - 75 (PDB: 5O31)
p: 76 - 142 (UniProt: Q02373)
p: 143 - 172 (PDB: 5O31)
d: 1 - 97 (UniProt: Q02827)
d: 98 - 116 (PDB: 5O31)
Z: 0 - 98 (UniProt: Q95KV7)
Z: 99 - 143 (PDB: 5O31)
| PDB | External Database | Details |
|---|---|---|
| Arg 129 | Gln 162 | conflict |
b: 46 - 80 (PDB: 5O31)
e: 1 - 105 (UniProt: Q02379)
| PDB | External Database | Details |
|---|---|---|
| Gly 27 | Lys 28 | conflict |
i: 40 - 118 (PDB: 5O31)
p: 4 - 75 (PDB: 5O31)
p: 76 - 142 (UniProt: Q02373)
p: 143 - 172 (PDB: 5O31)
d: 1 - 97 (UniProt: Q02827)
d: 98 - 116 (PDB: 5O31)
Z: 0 - 98 (UniProt: Q95KV7)
Z: 99 - 143 (PDB: 5O31)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 928832.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3726.6 | |
| All* | Total formula weight | 932558.8 |
