5O11
Crystal structure of PIM1 kinase in complex with small-molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase pim-1 | polymer | 298 | 34534.0 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
| 2 | A | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | non-polymer | 349.8 | 1 | Chemie (3NG) | |||
| 3 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 29 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Gln 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Asn 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Met 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34534.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 638.5 | |
| All* | Total formula weight | 35172.5 |
