5NZN
Complex of H275Y/S247N mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Neuraminidase | polymer | 388 | 42779.7 | 4 | UniProt (W5R8B8) Pfam (PF00064) UniProt (by SIFTS) (C3W6G3) | unidentified influenza virus | |
| 2 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 3 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | G, H, M, N, S... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 5 | AA, I, O, U (D, A, B, C) | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid | non-polymer | 284.4 | 4 | Chemie (G39) | |||
| 6 | BA, J, K, P, Q... (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 7 | L, X (A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 1362 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 82 - 469 (UniProt: W5R8B8)
| PDB | External Database | Details |
|---|---|---|
| Asn 247 | Ser 247 | engineered mutation |
| Tyr 275 | His 275 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 171118.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1157.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3351.8 | |
| All* | Total formula weight | 175627.6 |
