5NZN

Complex of H275Y/S247N mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Neuraminidase	polymer	388	42779.7	4	UniProt (W5R8B8) UniProt (by SIFTS) (C3W6G3)	unidentified influenza virus
2	E (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
3	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	G, H, M, N, S... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA) PubChem (271)
5	AA, I, O, U (D, A, B, C)	(3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid	non-polymer		284.4	4	Chemie (G39) PubChem (40640967) PubChem (40640969) PubChem (40640971) PubChem (44345914) PubChem (40640973) PubChem (58753598) PubChem (71038155) PubChem (71065667) PubChem (449381) PubChem (4631786) PubChem (95162772) PubChem (121452907) PubChem (124637832) PubChem (129886749) PubChem (134694948) PubChem (137378365)
6	BA, J, K, P, Q... (D, A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
7	L, X (A, C)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
8	CA, DA, EA, FA (A, B, C, D)	water	water		18.0	1362	Chemie (HOH)

Sequence modifications

A, B, C, D: 82 - 469 (UniProt: W5R8B8)

PDB	External Database	Details
Asn 247	Ser 247	engineered mutation
Tyr 275	His 275	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	171118.7
Branched	Number of molecules	2
	Total formula weight	1157.1
Non-Polymers*	Number of molecules	22
	Total formula weight	3351.8
All*	Total formula weight	175627.6

*Water molecules are not included.