5NYI
Crystal Structure of Hsp90-alpha N-Domain in complex with Resorcinol derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Heat shock protein HSP 90-alpha | polymer | 229 | 25938.2 | 1 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | A | 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide | non-polymer | 457.9 | 1 | Chemie (2EQ) | |||
| 3 | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A: 9 - 235 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Thr 31 | Ser 31 | conflict |
| Thr 39 | Ser 39 | conflict |
| Thr 50 | Ser 50 | conflict |
| Thr 52 | Ser 52 | conflict |
| Thr 53 | Ser 53 | conflict |
| Thr 63 | Ser 63 | conflict |
| Thr 68 | Ser 68 | conflict |
| Thr 72 | Ser 72 | conflict |
| Thr 113 | Ser 113 | conflict |
| Thr 129 | Ser 129 | conflict |
| Thr 140 | Ser 140 | conflict |
| Thr 164 | Ser 164 | conflict |
| Thr 165 | Ser 165 | conflict |
| Thr 169 | Ser 169 | conflict |
| Thr 211 | Ser 211 | conflict |
| Glu 224 | Lys 224 | conflict |
| Thr 231 | Ser 231 | conflict |
| Glu 236 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25938.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 457.9 | |
| All* | Total formula weight | 26396.1 |
