5NW8
Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp032 and Fasudil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 351 | 40998.6 | 1 | UniProt (P25321) Pfam (PF00069) | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B (D) | UPF0418 protein FAM164A | polymer | 18 | 1903.1 | 1 | UniProt (G3HK48) | Cricetulus griseus | |
| 3 | C (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 4 | D (A) | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | non-polymer | 291.4 | 1 | Chemie (M77) | |||
| 5 | E (D) | beta-D-ribopyranose | non-polymer | 150.1 | 1 | Chemie (RIP) | |||
| 6 | F, G (A, D) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
D: 11 - 28 (UniProt: G3HK48)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Arg 19 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42901.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 559.7 | |
| All* | Total formula weight | 43461.3 |
