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5NW1

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclobutanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 18)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D, G, J
(A, D, G, J)
Elongin-Bpolymer10411956.44UniProt (Q15370)
Pfam (PF00240)
Homo sapiens (Human)EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2B, E, H, K
(B, E, H, K)
Elongin-Cpolymer9710974.64UniProt (Q15369)
Pfam (PF03931)
Homo sapiens (Human)EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3C, F, I, L
(C, F, I, L)
Von Hippel-Lindau disease tumor suppressorpolymer16218806.34UniProt (P40337)
Pfam (PF01847)
Pfam (PF17211)
Homo sapiens (Human)Protein G7,pVHL
4M, N, O, P
(C, F, I, L)
(2~{S},4~{R})-1-[(2~{S})-2-(cyclobutylcarbonylamino)-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamidenon-polymer512.74Chemie (9BH)
5AA, BA, Q, R, S...
(K, L, A, B, C...)
waterwater18.0913Chemie (HOH)
Sequence modifications
B, E, H, K: 17 - 112 (UniProt: Q15369)
PDBExternal DatabaseDetails
Met 16-initiating methionine
C, F, I, L: 54 - 213 (UniProt: P40337)
PDBExternal DatabaseDetails
Gly 52-expression tag
Ser 53-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight166949.0
Non-Polymers*Number of molecules4
Total formula weight2050.7
All*Total formula weight168999.7
*Water molecules are not included.

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PDB entries from 2024-11-13

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