5NW1

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclobutanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 18)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Elongin-B	polymer	104	11956.4	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E, H, K (B, E, H, K)	Elongin-C	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, I, L (C, F, I, L)	Von Hippel-Lindau disease tumor suppressor	polymer	162	18806.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (Human)	Protein G7,pVHL
4	M, N, O, P (C, F, I, L)	(2~{S},4~{R})-1-[(2~{S})-2-(cyclobutylcarbonylamino)-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		512.7	4	Chemie (9BH)
5	AA, BA, Q, R, S... (K, L, A, B, C...)	water	water		18.0	913	Chemie (HOH)

Sequence modifications

B, E, H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	166949.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2050.7
All*	Total formula weight	168999.7

*Water molecules are not included.