5NW1
pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclobutanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 18)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J (A, D, G, J) | Elongin-B | polymer | 104 | 11956.4 | 4 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
2 | B, E, H, K (B, E, H, K) | Elongin-C | polymer | 97 | 10974.6 | 4 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
3 | C, F, I, L (C, F, I, L) | Von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18806.3 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
4 | M, N, O, P (C, F, I, L) | (2~{S},4~{R})-1-[(2~{S})-2-(cyclobutylcarbonylamino)-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 512.7 | 4 | Chemie (9BH) | |||
5 | AA, BA, Q, R, S... (K, L, A, B, C...) | water | water | 18.0 | 913 | Chemie (HOH) |
Sequence modifications
B, E, H, K: 17 - 112 (UniProt: Q15369)
C, F, I, L: 54 - 213 (UniProt: P40337)
PDB | External Database | Details |
---|---|---|
Met 16 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Gly 52 | - | expression tag |
Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 166949.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2050.7 | |
All* | Total formula weight | 168999.7 |