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5NVH

Crystal structure of TNKS2 in complex with 2-[4-(piperidin-1-yl)phenyl]-3,4-dihydroquinazolin-4-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, B)
Tankyrase-2polymer19121824.52UniProt (Q9H2K2)
Pfam (PF00644)
Homo sapiens (Human)TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
2B, D
(I, J)
Tankyrase-2polymer495493.22UniProt (Q9H2K2)Homo sapiens (Human)TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
3E, F, K, L
(A, B)
SULFATE IONnon-polymer96.14Chemie (SO4)
4G, M
(A, B)
ZINC IONnon-polymer65.42Chemie (ZN)
5H, N
(A, B)
2-(4-piperidin-1-ylphenyl)-3~{H}-quinazolin-4-onenon-polymer305.42Chemie (9B2)
6I, O
(I, B)
GLYCEROLnon-polymer92.12Chemie (GOL)
7J
(I)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
8P, Q, R, S
(A, I, B, J)
waterwater18.0328Chemie (HOH)
Sequence modifications
A, B: 946 - 1113 (UniProt: Q9H2K2)
PDBExternal DatabaseDetails
Met 923-initiating methionine
His 924-expression tag
His 925-expression tag
His 926-expression tag
His 927-expression tag
His 928-expression tag
His 929-expression tag
Ser 930-expression tag
Ser 931-expression tag
Gly 932-expression tag
Val 933-expression tag
Asp 934-expression tag
Leu 935-expression tag
Gly 936-expression tag
Thr 937-expression tag
Glu 938-expression tag
Asn 939-expression tag
Leu 940-expression tag
Tyr 941-expression tag
Phe 942-expression tag
Gln 943-expression tag
Ser 944-expression tag
Met 945-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight54635.5
Non-Polymers*Number of molecules11
Total formula weight1416.1
All*Total formula weight56051.6
*Water molecules are not included.

243531

PDB entries from 2025-10-22

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