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5NVF

Crystal structure of TNKS2 in complex with 2-[4-(pyridin-2-yl)phenyl]-3,4-dihydroquinazolin-4-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTankyrase-2polymer19121824.52UniProt (Q9H2K2)
Pfam (PF00644)
In PDB
Homo sapiens (Human)TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
2H, ITankyrase-2polymer495493.22UniProt (Q9H2K2)
In PDB
Homo sapiens (Human)TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
3A, BSULFATE IONnon-polymer96.14Chemie (SO4)
4A, BZINC IONnon-polymer65.42Chemie (ZN)
5A, B2-(4-pyridin-2-ylphenyl)-3~{H}-quinazolin-4-onenon-polymer299.32Chemie (9AW)
6HGLYCEROLnon-polymer92.11Chemie (GOL)
7waterwater18.0407Chemie (HOH)
Sequence modifications
A, B: 946 - 1113 (UniProt: Q9H2K2)
PDBExternal DatabaseDetails
Met 923-initiating methionine
His 924-expression tag
His 925-expression tag
His 926-expression tag
His 927-expression tag
His 928-expression tag
His 929-expression tag
Ser 930-expression tag
Ser 931-expression tag
Gly 932-expression tag
Val 933-expression tag
Asp 934-expression tag
Leu 935-expression tag
Gly 936-expression tag
Thr 937-expression tag
Glu 938-expression tag
Asn 939-expression tag
Leu 940-expression tag
Tyr 941-expression tag
Phe 942-expression tag
Gln 943-expression tag
Ser 944-expression tag
Met 945-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight54635.5
Non-Polymers*Number of molecules9
Total formula weight1205.8
All*Total formula weight55841.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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