5NTP
Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nuclear receptor ROR-gamma | polymer | 238 | 27629.9 | 1 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | A | (S)-N-(5-chloro-3-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-2-methylphenyl)-2-methylpyrimidine-5-carboxamide | non-polymer | 470.0 | 1 | Chemie (98E) | |||
| 3 | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A: 263 - 499 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27629.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 470.0 | |
| All* | Total formula weight | 28100.0 |
