5NND

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bromodomain-containing protein 4	polymer	127	15099.4	2	UniProt (O60885) Pfam (PF00439) In PDB	Homo sapiens (Human)	Protein HUNK1
2	D, E	Histone H3	polymer	17	2073.3	2	UniProt (Q5TEC6) UniProt (by SIFTS) (P68431) In PDB	Homo sapiens
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 44 - 168 (UniProt: O60885)

PDB	External Database	Details
Ser 42	-	expression tag
Met 43	-	expression tag

D, E: 4 - 20 (UniProt: Q5TEC6)

PDB	External Database	Details
Tyr 20	Leu 21	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	34345.3
Non-Polymers*	Number of molecules	1
	Total formula weight	62.1
All*	Total formula weight	34407.3

*Water molecules are not included.