5NJ8
Structural basis for aryl hydrocarbon receptor mediated gene activation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Aryl hydrocarbon receptor | polymer | 254 | 28423.4 | 2 | UniProt (P35869) Pfam (PF00010) Pfam (PF00989) In PDB | Homo sapiens (Human) | AhR,Class E basic helix-loop-helix protein 76,bHLHe76 |
2 | B, D | Aryl hydrocarbon receptor nuclear translocator | polymer | 239 | 26467.1 | 2 | UniProt (P53762) Pfam (PF00010) Pfam (PF00989) UniProt (by SIFTS) (P27540) In PDB | Mus musculus (Mouse) | ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta |
3 | E, G | DNA (5'-D(*GP*GP*TP*CP*AP*CP*GP*CP*AP*AP*CP*C)-3') | polymer | 12 | 3632.4 | 2 | Homo sapiens | ||
4 | F, H | DNA (5'-D(*GP*GP*TP*TP*GP*CP*GP*TP*GP*AP*CP*C)-3') | polymer | 12 | 3694.4 | 2 | Homo sapiens | ||
5 | A, B, C, D, H | ERBIUM (III) ION | non-polymer | 167.3 | 12 | Chemie (ER3) | |||
6 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) |
Sequence modifications
A, C: 23 - 273 (UniProt: P35869)
B, D: 85 - 345 (UniProt: P53762)
PDB | External Database | Details |
---|---|---|
Gly 20 | - | expression tag |
Pro 21 | - | expression tag |
Met 22 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 79 | - | expression tag |
Pro 80 | - | expression tag |
Gly 81 | - | expression tag |
Ser 82 | - | expression tag |
Asp 83 | - | expression tag |
Ala 84 | - | expression tag |
Ser 256 | Cys 256 | engineered mutation |
- | Val 274 | deletion |
- | Asp 275 | deletion |
- | Pro 276 | deletion |
- | Val 277 | deletion |
- | Ser 278 | deletion |
- | Met 279 | deletion |
- | Asn 280 | deletion |
- | Arg 281 | deletion |
- | Leu 282 | deletion |
- | Ser 283 | deletion |
- | Phe 284 | deletion |
- | Leu 285 | deletion |
- | Arg 286 | deletion |
- | Asn 287 | deletion |
- | Arg 288 | deletion |
- | Cys 289 | deletion |
- | Arg 290 | deletion |
- | Asn 291 | deletion |
- | Gly 292 | deletion |
- | Leu 293 | deletion |
- | Gly 294 | deletion |
- | Ser 295 | deletion |
- | Val 296 | deletion |
- | Lys 297 | deletion |
- | Glu 298 | deletion |
- | Gly 299 | deletion |
- | Glu 300 | deletion |
- | Pro 301 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 124434.6 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2066.2 | |
All* | Total formula weight | 126500.7 |