5NIE

Crystal structure of human LTA4H mutant R563A in open conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Leukotriene A-4 hydrolase	polymer	617	70106.7	3	UniProt (P09960) Pfam (PF17900) Pfam (PF01433) Pfam (PF09127) In PDB	Homo sapiens (Human)	LTA-4 hydrolase,Leukotriene A(4) hydrolase
2	A, B, C	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
3		water	water		18.0	154	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 610 (UniProt: P09960)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ala 563	Arg 564	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	210320.2
Non-Polymers*	Number of molecules	3
	Total formula weight	196.2
All*	Total formula weight	210516.4

*Water molecules are not included.