5NI9

Crystal structure of HLA-DRB1*04:01 with the alpha-enolase peptide 326-340

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class II histocompatibility antigen, DR alpha chain	polymer	189	21911.8	1	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (Human)	MHC class II antigen DRA
2	B (B)	HLA class II histocompatibility antigen, DRB1-4 beta chain	polymer	198	23102.7	1	UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (Human)	MHC class II antigen DRB1*4,DR4
3	C (C)	Alpha-enolase	polymer	15	1681.0	1	UniProt (P06733)	Homo sapiens	2-phospho-D-glycerate hydro-lyase,C-myc promoter-binding protein,Enolase 1,MBP-1,MPB-1,Non-neural enolase,NNE,Phosphopyruvate hydratase,Plasminogen-binding protein
4	D (A)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	1	Chemie (MRD)
5	E, G (A, B)	UREA	non-polymer		60.1	2	Chemie (URE)
6	F, H (B, C)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
7	I, J, K (A, B, C)	water	water		18.0	309	Chemie (HOH)

Sequence modifications

A: 1 - 181 (UniProt: P01903)

PDB	External Database	Details
Ser 182	-	expression tag
Ser 183	-	expression tag
Ala 184	-	expression tag
Asp 185	-	expression tag
Leu 186	-	expression tag
Val 187	-	expression tag
Pro 188	-	expression tag
Arg 189	-	expression tag

B: 1 - 190 (UniProt: P13760)

PDB	External Database	Details
Ser 191	-	expression tag
Ser 192	-	expression tag
Ala 193	-	expression tag
Asp 194	-	expression tag
Leu 195	-	expression tag
Val 196	-	expression tag
Pro 197	-	expression tag
Arg 198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46695.5
Non-Polymers*	Number of molecules	5
	Total formula weight	474.6
All*	Total formula weight	47170.1

*Water molecules are not included.