5NHZ
VIM-2_10b. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase class B VIM-2 | polymer | 266 | 28352.8 | 2 | UniProt (Q9K2N0) Pfam (PF00753) | Pseudomonas aeruginosa | BlaVIM-2,Class B carbapenemase VIM-2,Metallo beta-lactamase,Metallo-beta lactamase protein,Metallo-beta-lactamase VIM-2,VIM-2,VIM-2 beta-lactamase,VIM-2 class B metallo b-lactamase,VIM-2 type metallo-beta-lactamase |
| 2 | C, D, I, J, K (A, B) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 3 | E, O (A, B) | [(2~{R})-1-ethanoylsulfanyl-5-phenyl-pentan-2-yl]phosphonic acid | non-polymer | 302.3 | 2 | Chemie (8XZ) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G, H, M (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | L (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | N (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | P (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 9 | Q, R (A, B) | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56705.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1478.6 | |
| All* | Total formula weight | 58184.2 |
