5NHT
human 199.54-16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31979.4 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (Human) | MHC class I antigen A*2 |
| 2 | B (L) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (P) | Melanoma antigen recognized by T-cells 1 | polymer | 10 | 985.2 | 1 | UniProt (by SIFTS) (Q16655) | Homo sapiens | MART-1,Antigen LB39-AA,Antigen SK29-AA,Protein Melan-A,Melan-A/MART-1 (26-35) decapeptide |
| 4 | D (A) | T-cell receptor alpha variable 12-2,T-cell receptor, sp3.4 alpha chain | polymer | 211 | 23132.4 | 1 | UniProt (A0A075B6T6) UniProt (K7N5N2) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | T-cell receptor,sp3.4 beta chain |
| 5 | E (B) | T-cell receptor beta variable 19,TRB protein | polymer | 251 | 28292.4 | 1 | UniProt (A0A5B3) UniProt (A0A0C4ZKA8) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | V_segment translation product |
| 6 | F (H) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 7 | G, H (H) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 8 | I (H) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | J (H) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
H: 1 - 276 (UniProt: P01892)
L: 1 - 99 (UniProt: P61769)
A: 0 - 92 (UniProt: A0A075B6T6)
A: 93 - 202 (UniProt: K7N5N2)
B: 3 - 94 (UniProt: A0A5B3)
B: 101 - 244 (UniProt: A0A0C4ZKA8)
| PDB | External Database | Details |
|---|---|---|
| Val 245 | Ala 269 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ser 49 | Phe 70 | conflict |
| Gly 92 | Asn 113 | linker |
| PDB | External Database | Details |
|---|---|---|
| Asn 203 | - | expression tag |
| Asp 204 | - | expression tag |
| Gly 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Gly 207 | - | expression tag |
| Cys 208 | - | expression tag |
| Lys 209 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| Gln 95 | - | linker |
| Gly 96 | - | linker |
| Leu 97 | - | linker |
| Ala 98 | - | linker |
| Gly 99 | - | linker |
| Ala 100 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 171 | Ser 101 | conflict |
| Gln 245 | - | expression tag |
| Asp 246 | - | expression tag |
| Arg 247 | - | expression tag |
| Gly 248 | - | expression tag |
| Gly 249 | - | expression tag |
| Gly 250 | - | expression tag |
| Cys 251 | - | expression tag |
| Asp 252 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 96268.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 171.7 | |
| All* | Total formula weight | 96440.5 |
