5ND4

Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Kinesin-like protein KIF20A	polymer	501	56021.3	1	UniProt (P97329) Pfam (PF00225)	Mus musculus (House Mouse)	Kinesin-like protein 174,Rab6-interacting kinesin-like protein,Rabkinesin-6
2	B (A)	Tubulin alpha chain	polymer	412	45960.0	1	UniProt (F2Z4C1) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P81947)	Bos taurus (Bovine)
3	C (B)	Tubulin beta-2B chain	polymer	426	47809.7	1	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (Bovine)
4	D (C)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	E, H (C, A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
6	F (C)	TETRAFLUOROALUMINATE ION	non-polymer		103.0	1	Chemie (ALF) PubChem (5311325)
7	G (A)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
8	I (B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
9	J (B)	TAXOL	non-polymer		853.9	1	Chemie (TA1) PubChem (16757828) PubChem (16760674) PubChem (4666) PubChem (21458255) PubChem (23307219) PubChem (23412627) PubChem (23636632) PubChem (24848897) PubChem (24867246) PubChem (16760177) PubChem (16742549) PubChem (44323108) PubChem (44356961) PubChem (44403716) PubChem (21733096) PubChem (23307242) PubChem (23307253) PubChem (23307913) PubChem (24754091) PubChem (46781469) PubChem (24207713) PubChem (24791027) PubChem (49868078) PubChem (25200067) PubChem (54259298) PubChem (42613129) PubChem (42620039) PubChem (44155032) PubChem (44276363) PubChem (57908851) PubChem (57946364) PubChem (44279927) PubChem (44335735) PubChem (44291178) PubChem (44328863) PubChem (44342632) PubChem (44356895) PubChem (44378736) PubChem (58803237) PubChem (59844545) PubChem (45489039) PubChem (46782671) PubChem (59904698) PubChem (60123443) PubChem (71209844) PubChem (70943371) PubChem (71096818) PubChem (53313247) PubChem (53298534) PubChem (54259297) PubChem (54259299) PubChem (57489669) PubChem (73759783) PubChem (57999380) PubChem (58460861) PubChem (58777027) PubChem (58798493) PubChem (58596717) PubChem (59048611) PubChem (59042813) PubChem (58877402) PubChem (60005248) PubChem (59873251) PubChem (59914794) PubChem (59919147) PubChem (60123436) PubChem (60011010) PubChem (60147315) PubChem (66795656) PubChem (14060298) PubChem (176586897) PubChem (177678861) PubChem (36314) PubChem (60915) PubChem (177409) PubChem (184492) PubChem (70801836) PubChem (70842048) PubChem (70848451) PubChem (70856170) PubChem (441276) PubChem (73707502) PubChem (73759704) PubChem (89493063) PubChem (89847578) PubChem (90057663) PubChem (91122402) PubChem (91885464) PubChem (5460441) PubChem (5317123) PubChem (5321715) PubChem (101920282) PubChem (5352019) PubChem (121459571) PubChem (122361554) PubChem (6604028) PubChem (6604616) PubChem (6604814) PubChem (6713921) PubChem (6915727) PubChem (124747272) PubChem (124893098) PubChem (9875988) PubChem (126968948) PubChem (129395998) PubChem (129627423) PubChem (10748131) PubChem (132517454) PubChem (11320430) PubChem (11354895) PubChem (101598423) PubChem (134368714) PubChem (118528174) PubChem (134972678) PubChem (9854162) PubChem (9897470) PubChem (10033513) PubChem (137705323) PubChem (138106885) PubChem (10485732) PubChem (140731501) PubChem (140512017) PubChem (11506104) PubChem (11828953) PubChem (124747271) PubChem (124747273) PubChem (124747274) PubChem (14060299) PubChem (14060304) PubChem (14060306) PubChem (14060309) PubChem (146034004) PubChem (15983941) PubChem (153289350) PubChem (154037993) PubChem (155982214) PubChem (159121804) PubChem (160053861) PubChem (159716711) PubChem (160171678) PubChem (160585530) PubChem (163077211) PubChem (163077212) PubChem (163077209) PubChem (163284947) PubChem (126761000) PubChem (168322423) PubChem (169917882) PubChem (171036874) PubChem (175758871) PubChem (133052515) PubChem (133640187) PubChem (134715514) PubChem (143890766) PubChem (152743329) PubChem (154828192) PubChem (144453087) PubChem (160585532) PubChem (163077210) PubChem (163077213) PubChem (163077214) PubChem (163077215) PubChem (165084161) PubChem (166711459) PubChem (167423928) PubChem (170014955) PubChem (170362150)

Sequence modifications

A: 2 - 439 (UniProt: F2Z4C1)

PDB	External Database	Details
-	Gln 35	deletion
-	Met 36	deletion
-	Pro 37	deletion
-	Ser 38	deletion
-	Asp 39	deletion
-	Lys 40	deletion
-	Thr 41	deletion
-	Ile 42	deletion
-	Gly 43	deletion
-	Gly 44	deletion
-	Gly 45	deletion
-	Asp 46	deletion
-	Asp 47	deletion
-	Ser 48	deletion
-	Phe 49	deletion
-	Asn 50	deletion
-	Thr 51	deletion
-	Phe 52	deletion
-	Phe 53	deletion
-	Ser 54	deletion
-	Glu 55	deletion
-	Thr 56	deletion
-	Gly 57	deletion
-	Ala 58	deletion
-	Gly 59	deletion
-	Lys 60	deletion
Ser 136	Leu 136	conflict
Gly 265	Ile 265	conflict
Glu 358	Gln 358	conflict

B: 2 - 437 (UniProt: Q6B856)

PDB	External Database	Details
Ala 57	Thr 55	conflict
Val 172	Met 170	conflict
Ala 298	Ser 296	conflict
Val 318	Ile 316	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	149791.1
Non-Polymers*	Number of molecules	7
	Total formula weight	2399.1
All*	Total formula weight	152190.1

*Water molecules are not included.