5NBV
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-1-antitrypsin | polymer | 377 | 42340.4 | 1 | UniProt (P01009) Pfam (PF00079) | Homo sapiens (Human) | Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1 |
| 2 | B, C, D (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | E (A) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 19 - 394 (UniProt: P01009)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
| Leu 51 | Phe 75 | engineered mutation |
| Ala 59 | Thr 83 | engineered mutation |
| Ala 68 | Thr 92 | engineered mutation |
| Gly 70 | Ala 94 | engineered mutation |
| Ser 232 | Cys 256 | engineered mutation |
| Lys 342 | Glu 366 | engineered mutation |
| Ile 374 | Met 398 | engineered mutation |
| Ala 381 | Ser 405 | engineered mutation |
| Arg 387 | Lys 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42340.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 42616.7 |
