5NB6
Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Complement factor D | polymer | 232 | 24739.1 | 1 | UniProt (P00746) Pfam (PF00089) In PDB | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
2 | A | (2~{S},4~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-4-azanyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide | non-polymer | 490.4 | 1 | Chemie (8S2) | |||
3 | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 16 - 243 (UniProt: P00746)
PDB | External Database | Details |
---|---|---|
Ser 244 | - | expression tag |
Ala 245 | - | expression tag |
Ala 246 | - | expression tag |
Ala 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 24739.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 490.4 | |
All* | Total formula weight | 25229.6 |