5N4R
Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 2-(azepan-1-yl)-1-(1H-indol-3-yl)propan-1-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35632.6 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
| 2 | E | Pimtide | polymer | 14 | 1592.8 | 1 | Homo sapiens | ||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | 2-(azepan-1-yl)-1-(1~{H}-indol-3-yl)propan-1-one | non-polymer | 270.4 | 1 | Chemie (8MQ) | |||
| 5 | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37225.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 362.5 | |
| All* | Total formula weight | 37587.9 |
