5N4N
Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 3,4-dimethyl-5-(1H-1,2,4-triazol-3-yl)thiophene-2-carbonitrile
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35632.6 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
2 | B | Pimtide | polymer | 14 | 1592.8 | 1 | Homo sapiens | ||
3 | A | 3,4-dimethyl-5-(1~{H}-1,2,4-triazol-3-yl)thiophene-2-carbonitrile | non-polymer | 204.3 | 1 | Chemie (8M8) | |||
4 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
PDB | External Database | Details |
---|---|---|
Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 37225.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 204.3 | |
All* | Total formula weight | 37429.7 |