5N39
cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41193.7 | 1 | UniProt (P25321) Pfam (PF00069) | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase inhibitor alpha-like protein | polymer | 19 | 1993.3 | 1 | UniProt (A0A061IH64) UniProt (by SIFTS) (G3HK48) | Cricetulus griseus | |
| 3 | C (A) | (2~{S})-2-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrrolidin-1-ium | non-polymer | 206.3 | 1 | Chemie (8LZ) | |||
| 4 | D, E (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 5 | F, G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
B: 11 - 29 (UniProt: A0A061IH64)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| His -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 13 | Ser 14 | conflict |
| Gln 20 | Asn 21 | conflict |
| Ala 28 | Ser 29 | conflict |
| Ala 29 | Ser 30 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43187.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 598.9 | |
| All* | Total formula weight | 43785.9 |
