5N21
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-cell lymphoma 6 protein | polymer | 122 | 14100.4 | 2 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | C, E (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, F (A, B) | 2-[(2~{S})-1-[3-cyano-7-[(2-oxidanylidene-3,4-dihydro-1~{H}-quinolin-6-yl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]pyrrolidin-2-yl]ethanoic acid | non-polymer | 431.4 | 2 | Chemie (8HN) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 128 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gln 8 | Cys 8 | conflict |
| Arg 67 | Cys 67 | conflict |
| Asn 84 | Cys 84 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28200.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 933.8 | |
| All* | Total formula weight | 29134.6 |
