5N1X
Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | B-cell lymphoma 6 protein | polymer | 121 | 13981.3 | 1 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
2 | B, C | B-cell lymphoma 6 protein | polymer | 121 | 13981.3 | 2 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
3 | D | B-cell lymphoma 6 protein | polymer | 118 | 13693.9 | 1 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
4 | B, C, D | ~{N}-ethyl-5-pyridin-3-yl-pyrazolo[1,5-a]pyrimidin-7-amine | non-polymer | 239.3 | 4 | Chemie (8HH) | |||
5 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 9 - 128 (UniProt: P41182)
B, C: 7 - 127 (UniProt: P41182)
D: 9 - 125 (UniProt: P41182)
PDB | External Database | Details |
---|---|---|
Gln 8 | - | expression tag |
Arg 67 | Cys 67 | conflict |
Asn 84 | Cys 84 | conflict |
Ala 121 | Cys 121 | conflict |
PDB | External Database | Details |
---|---|---|
Gln 8 | Cys 8 | conflict |
Arg 67 | Cys 67 | conflict |
Asn 84 | Cys 84 | conflict |
Ala 121 | Cys 121 | conflict |
PDB | External Database | Details |
---|---|---|
Gln 8 | - | expression tag |
Arg 67 | Cys 67 | conflict |
Asn 84 | Cys 84 | conflict |
Ala 121 | Cys 121 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55637.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 957.1 | |
All* | Total formula weight | 56594.8 |