5MW6
Crystal structure of the BCL6 BTB-domain with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-cell lymphoma 6 protein | polymer | 126 | 14502.8 | 2 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | C, D (A) | 5-chloranyl-~{N}-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine | non-polymer | 334.2 | 2 | Chemie (RC0) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Ser 4 | - | expression tag |
| Gln 8 | Cys 8 | conflict |
| Arg 67 | Cys 67 | conflict |
| Asn 84 | Cys 84 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29005.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 668.4 | |
| All* | Total formula weight | 29673.9 |
