5MV8

Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Unconventional myosin-VIIb	polymer	527	60773.8	1	UniProt (Q6PIF6) Pfam (PF00784) Pfam (PF21989) Pfam (PF00373) Pfam (PF02174)	Homo sapiens (Human)
2	B (B)	cDNA FLJ51329, highly similar to Harmonin	polymer	130	14247.1	1	UniProt (B4DV53) Pfam (PF00595) UniProt (by SIFTS) (Q9Y6N9)	Homo sapiens (Human)
3	C, D, E, F, G... (A, B)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4	H (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	J, K (A, B)	water	water		18.0	380	Chemie (HOH)

Sequence modifications

A: 1609 - 2116 (UniProt: Q6PIF6)

PDB	External Database	Details
Met -5	-	initiating methionine
Gly -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
Ser 6	-	expression tag
Ser 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Lys 1605	-	expression tag
Glu 1606	-	expression tag
Lys 1607	-	expression tag
Leu 1608	-	expression tag
Asp 1660	Asn 1660	conflict
Asn 1665	Asp 1665	conflict
Glu 1669	Gln 1669	conflict
Glu 1786	Gln 1786	conflict

B: 428 - 552 (UniProt: B4DV53)

PDB	External Database	Details
Gly 423	-	expression tag
Ala 424	-	expression tag
Met 425	-	expression tag
Gly 426	-	expression tag
Ser 427	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75020.9
Non-Polymers*	Number of molecules	7
	Total formula weight	576.9
All*	Total formula weight	75597.7

*Water molecules are not included.