5MRV

Crystal structure of human carboxypeptidase O in complex with NvCI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Carboxypeptidase O	polymer	355	40907.9	2	UniProt (Q8IVL8) Pfam (PF00246)	Homo sapiens (Human)	CPO
2	C (C)	Metallocarboxypeptidase inhibitor	polymer	53	5956.7	1	UniProt (P86912)	Nerita versicolor (Four-tooth nerite)	MCPI,Carboxypeptidase inhibitor,NvCI
3	D, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)	Homo sapiens
4	E, F, G, I, J (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)	Homo sapiens
5	K, L, M (A, B, C)	water	water		18.0	521	Chemie (HOH)

Sequence modifications

A, B: 1 - 329 (UniProt: Q8IVL8)

PDB	External Database	Details
Glu -25	-	expression tag
Val -24	-	expression tag
Gln -23	-	expression tag
Ala -22	-	expression tag
Ser -21	-	expression tag
Trp -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
Pro -17	-	expression tag
Gln -16	-	expression tag
Phe -15	-	expression tag
Glu -14	-	expression tag
Lys -13	-	expression tag
Gly -12	-	expression tag
Ala -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Lys -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Lys -1	-	expression tag
Leu 0	-	expression tag
Ile 65	Met 85	variant
Arg 114	Ser 134	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87772.4
Non-Polymers*	Number of molecules	7
	Total formula weight	1236.9
All*	Total formula weight	89009.3

*Water molecules are not included.