5MRI
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sortilin | polymer | 696 | 77790.9 | 1 | UniProt (Q99523) Pfam (PF15902) Pfam (PF15901) In PDB | Homo sapiens (Human) | 100 kDa NT receptor,Glycoprotein 95,Gp95,Neurotensin receptor 3,NTR3 |
2 | B | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
5 | A | ~{N}-methyl-3-(3-methylbutyl)-5-oxidanyl-1,2,3-triazole-4-carboxamide | non-polymer | 212.2 | 1 | Chemie (Q9Y) | |||
6 | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence modifications
A: 45 - 723 (UniProt: Q99523)
PDB | External Database | Details |
---|---|---|
Met 617 | Val 650 | conflict |
Gly 724 | - | expression tag |
Ser 725 | - | expression tag |
Ala 726 | - | expression tag |
Met 727 | - | expression tag |
Ile 728 | - | expression tag |
Glu 729 | - | expression tag |
Gly 730 | - | expression tag |
Arg 731 | - | expression tag |
Gly 732 | - | expression tag |
Val 733 | - | expression tag |
Gly 734 | - | expression tag |
His 735 | - | expression tag |
His 736 | - | expression tag |
His 737 | - | expression tag |
His 738 | - | expression tag |
His 739 | - | expression tag |
His 740 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 77790.9 | |
Branched | Number of molecules | 2 |
Total formula weight | 1010.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 433.5 | |
All* | Total formula weight | 79235.3 |