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5MQL

Crystal structure of dCK mutant C3S in complex with masitinib and UDP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DDeoxycytidine kinasepolymer28934023.24UniProt (P27707)
Pfam (PF01712)
In PDB
Homo sapiens (Human)dCK
2A, B, C, DURIDINE-5'-DIPHOSPHATEnon-polymer404.24Chemie (UDP)
3AMasitinibnon-polymer498.61Chemie (G65)
4B, C2'-DEOXYCYTIDINE-5'-MONOPHOSPHATEnon-polymer307.22Chemie (DCM)
5CMAGNESIUM IONnon-polymer24.31Chemie (MG)
6waterwater18.018Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 260 (UniProt: P27707)
PDBExternal DatabaseDetails
Met -28-initiating methionine
Ser -27-expression tag
Tyr -26-expression tag
Tyr -25-expression tag
His -24-expression tag
His -23-expression tag
His -22-expression tag
His -21-expression tag
His -20-expression tag
His -19-expression tag
Leu -18-expression tag
Glu -17-expression tag
Ser -16-expression tag
Thr -15-expression tag
Ser -14-expression tag
Leu -13-expression tag
Tyr -12-expression tag
Lys -11-expression tag
Lys -10-expression tag
Ala -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Asn -5-expression tag
Leu -4-expression tag
Tyr -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Gly 0-expression tag
Ser 9Cys 9engineered mutation
Ser 45Cys 45engineered mutation
Ser 59Cys 59engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight136092.8
Non-Polymers*Number of molecules8
Total formula weight2754.0
All*Total formula weight138846.8
*Water molecules are not included.

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PDB entries from 2024-06-12

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