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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5MQ0

Structure of a spliceosome remodeled for exon ligation

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1IYeast UBC4 gene for ubiquitin-conjugating enzymepolymer9530200.71GenBank (4718)Saccharomyces cerevisiae (Baker's yeast)
2E5'-EXON OF UBC4 PRE-MRNApolymer206519.01Saccharomyces cerevisiae (Baker's yeast)
32S.cerevisiae chromosome II reading frame ORF YBR230cpolymer1175376267.41GenBank (536627)Saccharomyces cerevisiae (Baker's yeast)
46Saccharomyces cerevisiae strain T.52_2H chromosome XII sequencepolymer11235883.21GenBank (1039022925)Saccharomyces cerevisiae (Baker's yeast)
55Saccharomyces cerevisiae strain WI_C_MBSP_4 chromosome VII sequencepolymer17957444.91GenBank (1039023924)Saccharomyces cerevisiae (Baker's yeast)
6APre-mRNA-splicing factor 8polymer2413279867.51UniProt (P33334)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF08084)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
7CPre-mRNA-splicing factor SNU114polymer1008114174.01UniProt (P36048)
Pfam (PF03764)
Pfam (PF00679)
Pfam (PF16004)
Pfam (PF00009)
In PDB		Saccharomyces cerevisiae (Baker's yeast)114 kDa U5 small nuclear ribonucleoprotein component,Growth inhibitory protein 10
8HPre-mRNA-splicing factor CWC22polymer57767386.11UniProt (P53333)
Pfam (PF02847)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 22
9JPre-mRNA-splicing factor PRP46polymer45150771.31UniProt (Q12417)
Pfam (PF00400)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 1,PRP nineteen-associated complex protein 50,PRP19-associated complex protein 50,Pre-mRNA-processing protein 46
10KPre-mRNA-processing protein 45polymer37942548.71UniProt (P28004)
Pfam (PF02731)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
11LPre-mRNA-splicing factor BUD31polymer15718484.51UniProt (P25337)
Pfam (PF01125)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Bud site selection protein 31,Complexed with CEF1 protein 14
12MPre-mRNA-splicing factor CWC2polymer33938486.61UniProt (Q12046)
Pfam (PF16131)
Pfam (PF00076)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 2,PRP19-associated complex protein 40,Synthetic lethal with CLF1 protein 3
13NPre-mRNA-splicing factor SLT11polymer36440988.61UniProt (P38241)
Pfam (PF21369)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Extracellular mutant protein 2,Synthetic lethality with U2 protein 11
14OPre-mRNA-splicing factor CEF1polymer59067837.81UniProt (Q03654)
Pfam (PF00249)
Pfam (PF11831)
In PDB		Saccharomyces cerevisiae (Baker's yeast)PRP nineteen-associated complex protein 85,PRP19-associated complex protein 85
15PPre-mRNA-splicing factor CWC15polymer17519975.21UniProt (Q03772)
Pfam (PF04889)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 15
16RPre-mRNA-splicing factor CWC21polymer13515793.61UniProt (Q03375)
Pfam (PF08312)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 21
17SPre-mRNA-splicing factor CLF1polymer68782555.91UniProt (Q12309)
Pfam (PF05843)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Crooked neck-like factor 1,PRP19-associated complex protein 77,Synthetic lethal with CDC40 protein 3
18TPre-mRNA-splicing factor SYF1,PRE-MRNA-SPLICING FACTOR SYF1polymer877101875.91UniProt (Q04048)
Pfam (PF05843)
In PDB		Saccharomyces cerevisiae (Baker's yeast)PRP19-associated complex protein 90,Synthetic lethal with CDC40 protein 1,PRP19-associated complex protein 90,Synthetic lethal with CDC40 protein 1
19aPre-mRNA-splicing factor 18polymer25128414.41UniProt (P33411)
Pfam (PF02840)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
20cPre-mRNA-splicing factor SLU7polymer38244722.91UniProt (Q02775)
Pfam (PF11708)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Synthetic lethal with U2 snRNA protein 17,Synthetic lethal with U5 snRNA protein 7
21oPre-mRNA-processing factor 17polymer45552128.81UniProt (P40968)
Pfam (PF00400)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Cell division control protein 40
22XUNKNOWN PROTEINpolymer685805.11Saccharomyces cerevisiae (Baker's yeast)
23yPre-mRNA-splicing factor SYF2polymer21524850.71UniProt (P53277)
Pfam (PF08231)
In PDB		Saccharomyces cerevisiae (Baker's yeast)PRP19 complex protein 31,Synthetic lethal with CDC40 protein 2
24b, kSmall nuclear ribonucleoprotein-associated protein Bpolymer19622427.02UniProt (P40018)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)snRNP-B,Sm protein B,SmB
25d, nSmall nuclear ribonucleoprotein Sm D3polymer10111240.12UniProt (P43321)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Sm-D3,snRNP core protein D3
26e, pSmall nuclear ribonucleoprotein Epolymer9410385.12UniProt (Q12330)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)snRNP-E,Sm protein E,SmE
27f, qSmall nuclear ribonucleoprotein Fpolymer869669.92UniProt (P54999)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)snRNP-F,Sm protein F,SmF
28g, rSmall nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)snRNP-G,Sm protein G,SmG
29h, lSmall nuclear ribonucleoprotein Sm D1polymer14616296.82UniProt (Q02260)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Sm-D1,snRNP core protein D1
30j, mSmall nuclear ribonucleoprotein Sm D2polymer11012876.12UniProt (Q06217)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Sm-D2,snRNP core protein D2
31VPre-mRNA-splicing factor ATP-dependent RNA helicase PRP22polymer1145130187.41UniProt (P24384)
Pfam (PF00575)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF04408)
Pfam (PF21010)
Pfam (PF07717)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
32WU2 small nuclear ribonucleoprotein A'polymer23827232.31UniProt (Q08963)
Pfam (PF14580)
In PDB		Saccharomyces cerevisiae (Baker's yeast)U2 snRNP A',Looks exceptionally like U2A protein 1
33YU2 small nuclear ribonucleoprotein B''polymer11112850.91UniProt (P40567)
Pfam (PF13893)
In PDB		Saccharomyces cerevisiae (Baker's yeast)U2 snRNP B''
3433'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASEpolymer3873.51Saccharomyces cerevisiae (Baker's yeast)
35sPre-mRNA-splicing factor SNT309polymer17520741.51UniProt (Q06091)
In PDB		Saccharomyces cerevisiae (Baker's yeast)PRP19-associated complex protein 25,Synergistic to PRP19 mutation protein 309
36t, u, v, wPre-mRNA-processing factor 19polymer50356629.84UniProt (P32523)
Pfam (PF08606)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
376MAGNESIUM IONnon-polymer24.33Chemie (MG)
386POTASSIUM IONnon-polymer39.12Chemie (K)
39AINOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
40CGUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
41L, M, NZINC IONnon-polymer65.46Chemie (ZN)
Sequence modifications
T: 1 - 859 (UniProt: Q04048)
T: 1000 - 1017 (PDB: 5MQ0)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains46
Total formula weight2204158.9
Non-Polymers*Number of molecules13
Total formula weight1726.8
All*Total formula weight2205885.7
*Water molecules are not included.

223790

PDB entries from 2024-08-14

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